Brody Human Pharmacology, 5th Edition by Lynn Crespo Test Bank

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Brody Human Pharmacology, 5th Edition by Lynn Crespo Test Bank

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WITH ANSWERS

Brodys Human Pharmacology, 5th Edition by Lynn Crespo Test Bank

Wecker: Brodys Human Pharmacology, 5th Edition

Chapter 02: Pharmacokinetics: Absorption, Distribution, Metabolism, and Elimination

Test Bank

Multiple Choice

  1. Which of the following features of a drug would enhance its uptake in the GI tract?
    1. Polar
    2. Water soluble
    3. Ionized
    4. Low molecular weight
    5. Low concentration gradient

 

ANS: D. Of the options given, only a low molecular weight will increase uptake of a drug by the GI tract.

 

  1. Which organ contains predominantly tight intercellular junctions, thereby restricting its uptake of drugs?

 

  1. Kidney
  2. Liver
  3. Brain
  4. Heart
  5. Lungs

 

ANS: C. The brain contains tight intercellular junctions, forming the blood-brain barrier.

 

  1. Drugs commonly undergo all of the following types of metabolism in the liver EXCEPT FOR:

 

  1. Polymerization
  2. Conjugation
  3. Oxidation
  4. Reduction
  5. Hydrolysis

 

ANS: A. Polymerization is not a common process by which drugs are hepatically metabolized.

 

  1. Which organ contains predominantly tight intercellular junctions, thereby restricting its uptake of drugs?

 

  1. Kidney
  2. Liver
  3. Brain
  4. Heart
  5. Lungs

 

ANS: C. The brain contains tight intercellular junctions, forming the blood-brain barrier.

  1. Drugs commonly undergo all of the following types of metabolism in the liver EXCEPT FOR:

    1. Polymerization
    2. Conjugation
    3. Oxidation
    4. Reduction
    5. Hydrolysis

 

ANS: A. Polymerization is not a common process by which drugs are hepatically metabolized.

 

 

Wecker: Brodys Human Pharmacology, 5th Edition

Chapter 04: Drug Development, Regulation, and Prescription Writing

 

Test Bank

Multiple Choice

  • The following characterizes Phase 3 trials of drug development:
    1. Conducted on several thousand patients with specific diseases to determine overall risk-benefit relationships
    2. Conducted on a small number of normal volunteers to determine safe dosage range and pharmacokinetic parameters
    3. Conducted on animals to determine what potential toxicities exist and at what serum levels those toxicities are manifest
    4. Surveillance of a drug after release on the market to determine whether any previously undetected side effects develop after extended use of the drug on large populations
    5. Conducted on several hundred patients with specific diseases to determine short-term safety and effectiveness of the drug

 

ANS: A.

 

  • In the United States, a rare disease is defined as one affecting fewer than what number of people?
    1. 25,000
    2. 50,000
    3. 100,000
    4. 200,000
    5. 400,000

 

ANS: D.

 

  • Which of the following pairs of Latin abbreviations and English meanings is correct?
    1. QID = daily
    2. AC = after meals
    3. PO = by mouth
    4. BID = every 2 days
    5. = with

ANS: C.

 

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