Rang & Dale Pharmacology by Humphrey P. Rang Test Bank

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Rang & Dale Pharmacology by Humphrey P. Rang Test Bank

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WITH ANSWERS
Rang & Dales Pharmacology by Humphrey P. Rang Test Bank

Rang: Rang & Dales Pharmacology, 7th Edition

 

Test Bank

 

Chapter 2: How drugs act: general principles

 

MULTIPLE CHOICE

 

  1. The concentration of a drug required to occupy 50 percent of its receptor sites is

 

    1. the concentration required to produce the maximum physiological effect
    2. directly proportional to the drugs affinity for its receptor
    3. inversely proportional to the drugs affinity for its receptor
    4. directly proportional to the drugs intrinsic efficacy
    5. usually determined with the Schild equation

 

Answer c: inversely proportional to the drugs affinity for its receptor

 

  1. In the presence of a competitive antagonist, the agonist log-concentration effect curve is

 

    1. shifted to the right without a change in slope or maximum effect
    2. shifted to the left without a change in slope or maximum effect
    3. shifted to the right with a decreased slope and maximum effect
    4. shifted to the left with a decreased slope and maximum effect
    5. not shifted right or left but shows a decreased maximum effect

 

Answer a: shifted to the right without a change in slope or maximum effect

 

  1. The magnitude of the response to a drug is related to the

 

    1. total number of receptors for the drug
    2. number of receptors occupied by the drug
    3. number of vacant receptors in the tissue
    4. number of spare receptors in the tissue
    5. number of phosphorylated receptors in the tissue

 

Answer b: number of receptors occupied by the drug

 

  1. The Schild equation shows that the concentration ratio of an agonist required to occupy the same number of receptors in the absence and presence of a competitive antagonist is determined by the

 

    1. equilibrium constant of the agonist
    2. affinity of the agonist for its receptor
    3. equilibrium constant of the antagonist
    4. total number of available receptors
    5. number of spare receptors in the tissue

 

Answer c: equilibrium constant of the antagonist

 

  1. A partial agonist is typically a drug that

 

    1. has low affinity for its receptor
    2. can only occupy a small fraction of its receptors
    3. can only produce a submaximal response
    4. requires high doses to produce a maximal response
    5. increases the number of spare receptors

 

Answer c: can only produce a submaximal response

 

  1. A type of drug that reduces the slope and maximum response of an agonist is

 

    1. a non-competitive antagonist
    2. a competitive antagonist
    3. a physiologic antagonist
    4. an inverse agonist
    5. a partial agonist

 

Answer a: a non-competitive antagonist

 

  1. Drugs that form covalent bonds with their receptors are usually

 

    1. reversible competitive antagonists
    2. irreversible competitive antagonists
    3. partial agonists
    4. inverse agonists
    5. inverse antagonists

 

Answer b: irreversible competitive antagonists

 

  1. A gradual decrease in the number of drug receptors is most likely to result from exposure to

 

    1. a competitive antagonist
    2. a non-competitive antagonist
    3. an agonist
    4. an inverse agonist
    5. an antimetabolite

 

Answer c: an agonist

 

  1.  The total number of receptor binding sites in a preparation and the binding equilibrium constant can be determined from a

 

    1. total binding versus drug concentration curve
    2. dose-response curve
    3. Hill-Langmuir equation
    4. Scatchard plot
    5. Schild plot

 

Answer d: Scatchard plot

 

  1.  Receptor desensitization typically results from

 

    1. endocytosis of receptors
    2. exposure to an inverse agonist
    3. irreversible agonist binding
    4. spare receptors
    5. phosphorylation of receptor protein

 

Answer e: phosphorylation of receptor protein

 

 

Rang: Rang & Dales Pharmacology, 7th Edition

 

Test Bank

 

Chapter 16: Purines

 

MULTIPLE CHOICE

 

  1. Urinary levels of 5-hydroxyindole acetic acid provide an indication of the bodys production of

 

  1. adenosine
  2. serotonin
  3. adenosine triphosphate
  4. histamine
  5. endothelin

 

Answer b: serotonin

 

  1. Some of the effects of theophylline are attributed to antagonism of

 

  1. glutamate
  2. 5-hydroxytrypamine
  3. adenosine
  4. norepinephrine
  5. histamine

 

Answer c: adenosine

 

  1. The effects of chemical mediators on platelets include

 

  1. stimulation of platelet aggregation by adenosine diphosphate
  2. stimulation of platelet aggregation by adenosine
  3. inhibition of platelet aggregation by adenosine diphosphate
  4. inhibition of platelet aggregation by histamine
  5. inhibition of platelet aggregation by serotonin

 

Answer a: stimulation of platelet aggregation by adenosine diphosphate

 

  1. Cyproheptadine is useful in treating carcinoid syndrome because of its ability to

 

  1. activate 5-HT1 receptors
  2. block 5-HT1 receptors
  3. activate 5-HT2 receptors
  4. block 5-HT2 receptors
  5. activate 5-HT4 receptors

 

Answer d: block 5-HT2 receptors

 

  1. In persons with irritable bowel syndrome whose predominant symptom is constipation, intestinal peristaltic activity may be increased by drugs that

 

  1. activate 5-HT1 receptors
  2. block 5-HT1 receptors
  3. activate 5-HT2 receptors
  4. block 5-HT2 receptors
  5. activate 5-HT4 receptors

 

Answer e: activate 5-HT4 receptors

 

  1. Activation of 5-HT1D receptors is usually beneficial in persons suffering from

 

  1. carcinoid syndrome
  2. nausea and vomiting
  3. migraine headache
  4. constipation
  5. anxiety

 

Answer c: migraine headache

 

  1. Retroperitoneal and mediastinal fibrosis is a characteristic adverse effect of

 

  1. methysergide
  2. ergotamine
  3. bromocriptine
  4. sumatriptan
  5. tegaserod

 

Answer a: methysergide

 

  1. Blockade of 5-HT3 receptors in vagal afferent neurons is useful in preventing

 

  1. migraine headache
  2. serotonin syndrome
  3. platelet aggregation
  4. nausea and vomiting
  5. constipation

 

Answer d: nausea and vomiting

 

 

Rang: Rang & Dales Pharmacology, 7th Edition

 

Test Bank

 

Chapter 32:  The pituitary and the adrenal cortex

 

MULTIPLE CHOICE

 

  1. The anabolic effects of growth hormone are mediated primarily by

 

  1. somatotropin
  2. somatostatin
  3. somatomedin
  4. somatotrophin
  5. somatorelin

 

Answer c: somatomedin

 

  1. During breast feeding, prolactin inhibits the release or response to

 

  1. oxytocin
  2. estradiol
  3. progesterone
  4. gonadotrophins
  5. hydrocortisone

 

Answer d: gonadotrophins

 

  1. The effects of fludrocortisone can be antagonized by

 

  1. spironolactone
  2. beclomethasone
  3. metyrapone
  4. aldosterone
  5. aminoglutethimide

 

Answer a: spironolactone

 

  1. Octreotide is correctly described as a

 

  1. short-acting analogue of somatotrophin
  2. long-acting analogue of somatotrophin
  3. short-acting analogue of somatostatin
  4. long-acting analogue of somatostatin
  5. long-acting analogue of somatomedin

 

Answer d: long-acting analogue of somatostatin

 

  1. In the basic transactivation mechanism of glucocorticoid receptor control of gene expression, the ligand-bound glucocorticoid receptor dimer binds to

 

  1. nuclear factor kappa B sites
  2. regulatory sites of Fos/Jun transcription factors
  3. negative glucocorticoid response elements
  4. positive glucocorticoid response elements
  5. negative transcription factors

 

Answer d: positive glucocorticoid response elements

 

  1. Metyrapone inhibits the biosynthesis of

 

  1. only corticosterone
  2. only hydrocortisone
  3. only dehydroepiandrosterone
  4. both corticosterone and hydrocortisone
  5. corticosterone, hydrocortisone, and dehydroepiandrosterone

 

Answer d: both corticosterone and hydrocortisone

 

  1. Insulin-like growth factor-1 causes feedback inhibition of the secretion of

 

  1. prolactin
  2. melanocyte-stimulating hormone
  3. growth hormone
  4. corticotropin
  5. thyrotropin

 

Answer c: growth hormone

 

  1. Polyuria may result from inhibition of antidiuretic hormone by

 

  1. desmopressin
  2. oxytocin
  3. carbamazepine
  4. ibuprofen
  5. lithium

 

Answer e: lithium

 

  1. The adverse effects of high-dose or chronic administration of prednisone include

 

  1. muscle hypertrophy
  2. cataracts
  3. decreased abdominal fat
  4. thickened skin
  5. hypotension

 

Answer b: cataracts

 

  1.  Cabergoline inhibits the anterior pituitary secretion of

 

  1. prolactin
  2. melanocyte-stimulating hormone
  3. thyrotropin
  4. somatotrophin
  5. corticotrophin

 

Answer a: prolactin

 

  1. The treatment of diabetes insipidus includes nasal administration of

 

  1. vasopressin
  2. desmopressin
  3. demeclocycline
  4. octreotide
  5. budesonide

 

Answer b: desmopressin

 

 

Rang: Rang & Dales Pharmacology, 7th Edition

 

Test Bank

 

Chapter 48: Drug addiction, dependence, and abuse

 

MULTIPLE CHOICE

 

  1. All dependence-producing drugs act via different pathways to cause

 

  1. depletion of norepinephrine in the locus coeruleus
  2. depletion of dopamine in nigrostriatal pathways
  3. depletion of glutamate in meso-limbic pathways
  4. the release of glutamate in the frontal cortex
  5. the release of dopamine in the nucleus accumbens

 

Answer e: the release of dopamine in the nucleus accumbens

 

  1. Chronic administration of morphine is believed to cause tolerance by

 

  1. increasing expression of adenylate cyclase
  2. decreasing expression of adenylate cyclase
  3. increasing expression of guanylate cyclase
  4. decreasing expression of guanylate cyclase
  5. increasing expression of a-adrenoceptors

 

Answer a: increasing expression of adenylate cyclase

 

  1. Nicotine use often leads to drug dependence by activation of nicotinic receptors in the

 

  1. nucleus accumbens
  2. hippocampus
  3. ventral tegmental area
  4. cerebral cortex
  5. striatum

 

Answer c: ventral tegmental area

 

  1. Disulfiram has been used to facilitate abstinence from ethanol based on its ability to inhibit

 

  1. the mesolimbic dopaminergic pathway
  2. ethanol withdrawal symptoms
  3. alcohol dehydrogenase
  4. aldehyde dehydrogenase
  5. aldehyde oxidase

 

Answer d: aldehyde dehydrogenase

 

  1. The effects that result from smoking marijuana include

 

  1. improved motor coordination
  2. improved memory
  3. increased creativity
  4. loss of appetite
  5. conjunctival vasodilatation

 

Answer e: conjunctival vasodilatation

 

  1. Which drug is used in the treatment of drug dependence because of its ability to reduce withdrawal symptoms?

 

  1. clonidine
  2. methadone
  3. bupropion
  4. naltrexone
  5. acamprosate

 

Answer a: clonidine

 

  1. The fetal alcohol syndrome is associated with malformations that typically include

 

  1. increased cranial circumference
  2. abnormal limb development
  3. abnormal facial development
  4. neural tube birth defects
  5. cleft palate

 

Answer c: abnormal facial development

 

  1. A sustained-release formulation of bupropion is used to facilitate abstinence in persons who are addicted to

 

  1. ethanol
  2. cocaine
  3. nicotine
  4. heroin
  5. marijuana

 

Answer c: nicotine

 

  1. Metabolism of the amount of ethanol contained in substantial quantities of alcoholic beverages may lead to a depletion of

 

  1. essential amino acids
  2. acetaldehyde
  3. reduced nicotinamide adenine dinucleotide (NADH)
  4. nicotinamide adenine dinucleotide (NAD+)
  5. lactate

 

Answer d: nicotinamide adenine dinucleotide (NAD+)

 

  1. Moderate ingestion of ethanol reduces mortality associated with

 

  1. lung cancer
  2. liver disease
  3. coronary heart disease
  4. hypertension
  5. renal disease

 

Answer: c: coronary artery disease

 

  1. In this decade, the incidence of cigarette smoking is

 

  1. increasing in developing countries
  2. decreasing in developing countries
  3. increasing in the UK but decreasing in developing countries
  4. decreasing in the UK but increasing in developing countries
  5. increasing in all countries studied

 

Answer d: decreasing in the UK but increasing in developing countries

 

  1.  Ingestion of ethanol typically increases the secretion of

 

  1. testosterone
  2. antidiuretic hormone
  3. adrenocorticotrophic hormone
  4. growth hormone
  5. glucagon

 

Answer c: adrenocorticotrophic hormone

 

 

Rang: Rang & Dales Pharmacology, 7th Edition

 

Test Bank

 

Chapter 60:  Drug discovery and development

 

MULTIPLE CHOICE

 

  1. Since 1980, the drug development process has been characterized by

 

  1. rising sales and development costs
  2. rising sales and declining development costs
  3. declining sales and rising development costs
  4. declining sales and development costs
  5. increasing registration of new compounds

 

Answer a: rising sales and development costs

 

  1. Phase II clinical trials are primarily concerned with determining

 

  1. drug safety in a small group of normal subjects
  2. drug efficacy and dosage in a small group of diseased patients
  3. drug pharmacokinetics in a large group of diseased patients
  4. statistical evidence of drug efficacy in thousands of subjects
  5. long-term adverse effects after a drug has been marketed

 

Answer b: drug efficacy and dosage in a small group of diseased patients

 

  1. The main disadvantage of natural products as lead compounds for drug development is their

 

  1. rarity
  2. complexity
  3. toxicity
  4. inactivity
  5. insolubility

 

Answer b: complexity

 

  1. The simultaneous preparation of hundreds or thousands of related compounds uses a process called

 

  1. high throughput chemistry
  2. chaotic chemistry
  3. fractal chemistry
  4. optimized chemistry
  5. combinatorial chemistry

 

Answer e: combinatorial chemistry

 

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