The Biology of Cancer 2nd Edition By Robert A. Test Bank

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The Biology of Cancer 2nd Edition By Robert A. Test Bank

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The Biology of Cancer 2nd Edition By Robert A. Test Bank

The Biology of Cancer, 2nd Edition, Question Bank

2014 Garland Science

Chapter 6: Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Level 1: Comprehension of reading, knowledge of terminology

Level 2: Understanding and application of information to compare and contrast or interpretation of data

Level 3: Analysis and application of information to a problem, an experiment, a secondary concept, or previous knowledge

  • Following serum starvation, if normal fibroblasts were treated with cycloheximide to shut down cellular protein synthesis, then, when exposed to fresh serum, the cells would (Level 2)
  1. Continue to remain viable in a quiescent state.
  2. Express immediate early genes.
  3. Enter a state of senescence.
  4. None of the above.

 

  • What happens in cells following stimulation with growth factors? (Level 2)
  1. The transcription of all genes required for growth and replication occurs immediately.
  2. There is a delay of several hours before transcription of genes needed for growth occurs.
  3. Some genes required for growth are transcribed immediately, while others are transcribed later, after new transcription factors have been synthesized.
  4. Cell death occurs.
  5. None of the above.

 

  • Which of the following is NOT true of the son of sevenless (Sos) protein? (Level 2)
  1. It is a guanine nucleotide exchange factor (GEF).
  2. It is a GTPase-activating protein (GAP).
  3. It is able to activate Ras.
  4. It was initially identified in Drosophila melanogaster.
  5. None of the above.

 

  • Which of the following domains of Src is its catalytic domain? (Level 1)
  1. SH1
  2. SH2
  3. SH3
  4. C-terminus
  5. N- terminus

 

  • The SH2 domains of tyrosine kinases function to (Level 3)
  1. Catalyze activation of downstream pathways.
  2. Act as receptors for phosphotyrosine-containing oligopeptide ligands.
  3. Localize the protein to specific sites in the cell.
  4. B and C.
  5. None of the above.

 

  • Which of the following signaling pathways is in the correct order? (Level 2)
  1. Receptor Sos Grb2 Ras
  2. Receptor Ras Sos Grb2
  3. Receptor Sos Ras Grb2
  4. Receptor Grb2 Ras Sos
  5. Receptor Grb2 Sos Ras

 

  • Which of the following molecules is NOT a downstream effector of Ras? (Level 2)
  1. Ral-GEFs
  2. PI3K
  3. Grb2
  4. Raf
  5. None of the above

 

  • Which of the following statements about AKT is FALSE? (Level 3)
  1. AKT is activated downstream of PI3K.
  2. AKT activation may inhibit apoptosis through downstream inactivation of Bad.
  3. AKT activation may result in activation of mTOR.
  4. AKT is tethered to the plasma membrane by PIP3.
  5. None of the above.

 

  • Which of the following pathways activated downstream of Ras can result in reorganization of the cytoskeleton, playing a role in cell motility? (Level 2)
  1. MEK
  2. PI3K
  3. Ral BP1
  4. Erk1
  5. None of the above

 

  • Which of the following is NOT true of -catenin? (Level 2)
  1. It binds directly to the Wnt protein.
  2. It associates with Tcf/Lef transcription factors in the nucleus, driving cell proliferation.
  3. It can be degraded when bound to active GSK-3.
  4. It exists in a soluble pool in the cytosol.
  5. None of the above.

 

  • In normal cells, Ras-GAPs trigger GTPase activity in order to (Level 2)
  1. Maintain Ras in its active state.
  2. Enhance downstream signaling by Ras effectors.
  3. Promote cellular proliferation.
  4. Inactivate Ras signaling.
  5. A and B.

 

  • Which of the following does NOT occur downstream of epidermal growth factor binding to its receptor? (Level 3)
  1. NF1 is phosphorylated.
  2. NF1 levels are increased.
  3. Ras is GTP-loaded.
  4. The MAPK pathway is activated.
  5. None of the above.

 

Answers

  • B
  • C
  • B
  • A
  • D
  • E
  • C
  • E
  • C
  • A
  • D
  • B

The Biology of Cancer, 2nd Edition, Question Bank

2014 Garland Science

Chapter 7 Tumor Suppressor Genes

Level 1: Comprehension of reading, knowledge of terminology

Level 2: Understanding and application of information to compare and contrast or interpretation of data

Level 3: Analysis and application of information to a problem, an experiment, a secondary concept, or previous knowledge

  • When a normal cell and a cancer cell were fused, the resulting hybrids lost the ability to form tumors in mice. This suggests that (Level 3)
  1. The cancer cell alleles are dominant over the normal cell alleles.
  2. The cancer cell alleles are recessive to the normal cell alleles.
  3. The normal and cancer cell alleles are co-dominant.
  4. The original tumor formed as a result of infection by a tumor virus.
  5. None of the above.

 

  • Sporadic cases of retinoblastoma require (Level 3)
    1. One inactivating somatic mutation in one copy of Rb.
    2. Two somatic inactivating mutations, one in each of the two copies of Rb.
    3. One somatic mutation in Rb, leading to its activation.
    4. Two somatic mutations in a copy of Rb, leading to its activation.
    5. None of the above.

 

  • Loss of heterozygosity (LOH) at a given locus may occur as the result of (Level 2)
  1. Mitotic recombination.
  2. Gene conversion.
  3. Loss of a chromosomal region.
  4. All of the above.

 

  • Single nucleotide polymorphism markers (SNPs) are found approximately how far apart across the genome? (Level 1)
  1. Every 1 megabase
  2. Every 10 megabases
  3. Every 1 kilobase
  4. Every 10 kilobases
  5. None of the above

 

  • Which of the following is TRUE of methylation in cancer cells? (Level 2)
  1. Overall levels of methylation throughout the cancer cell genome often increase.
  2. There is an increase in DNA methyltransferase enzyme activity.
  3. Areas of CpG islands are hypomethylated.
  4. Areas of CpG islands become methylated inappropriately.
  5. None of the above.

 

  • The APC protein (Level 2)
  1. Is essential for degrading -catenin.
  2. Causes increased activation of -catenin.
  3. Helps to regulate cell motility.
  4. A and C.
  5. None of the above.

 

  • Which of the following statements about NF1 is FALSE? (Level 2)
  1. It regulates Ras signaling through positive feedback control mechanisms.
  2. Cells lacking NF1 have higher levels of GTP-bound Ras.
  3. NF1 is known as a Ras-GAP.
  4. B and C.
  5. None of the above.

 

  • You are studying a cell line in which the loss of just one copy of a tumor suppressor gene provides a growth advantage for the cells. This would be an example of genetic (Level 1)
  1. Unilateral mutation.
  2. None of the above.

 

  • HIF-1 levels may go up when (Level 3)
  1. Oxygen conditions are at normal physiologic levels.
  2. Cells are experiencing hypoxic conditions.
  3. Oxygen levels are high.
  4. HIF-1 is bound to pVHL.
  5. C and D.

 

  • Which of the following genes is NOT classified as a tumor suppressor? (Level 2)
  1. MGMT
  2. p16INK4A
  3. PTEN
  4. VHL
  5. None of the above

 

  • Inactivation of tumor suppressor genes can occur as the result of (Level 2)
  1. Somatic mutation.
  2. Promoter demethylation.
  3. Loss of heterozygosity.
  4. A and C.
  5. None of the above.

 

  • You are studying cancer cells, and hypothesize that you have found a previously unidentified tumor suppressor gene. Which of the following results would support your hypothesis? (Level 3)
  1. You have found loss of heterozygosity in the locus containing your gene in a number of human lung cancer samples.
  2. You have identified a gain-of-function mutation in this gene that results in the transformation of normal cells.
  3. Functional analysis has revealed that the wild-type form of the gene that you have identified serves to drive proliferation.
  4. B and C.
  5. None of the above.

 

Answers

  • B
  • B
  • E
  • C
  • D
  • D
  • A
  • C
  • B
  • A
  • D
  • A

 

 

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